Formulation, Characterisation, and Evaluation of Curcumin Nanoparticles in Experimental Models of Alzheimer’s Disease

Pasrija Kanika; Alka Patel; Bichitrananda Tripathy

doi:10.65807/prob.sci.2025.2.2.4

editor.probsci@gmail.com

Probecell Science

Open Access | E-ISSN: 3049-1584

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Formulation, Characterisation, and Evaluation of Curcumin Nanoparticles in Experimental Models of Alzheimer’s Disease

Author(s): Pasrija Kanika, Alka Patel, Bichitrananda Tripathy

Email(s): alkarpi55@gmail.com

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Published In: Volume - 2, Issue - 2, Year - 2025

DOI: 10.65807/prob.sci.2025.2.2.4

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ABSTRACT:
Alzheimer's disease (AD) is a neurodegenerative disorder involving the amyloid-β plaque deposition, tau pathology, synaptic dysfunction, and impairment in cognition. Despite years of research, all current treatment modalities are symptomatic rather than effective in preventing disease progression. Curcumin, a natural polyphenol extracted from the plant Curcuma longa, possesses potent antioxidant, anti-inflammatory, and anti-amyloid features, but its therapeutic application is hampered by inadequate aqueous solubility, low permeability across the blood-brain barrier (BBB) and poor systemic bioavailability. The goal of this study is to innovate and evaluate the neuroprotection of curcumin-loaded polymeric nanoparticles in Alzheimer\'s disease experimental models. The particle size of formulation F6 was optimal, the polydispersity index was minimised, the efficiency of encapsulation maximised, and a long-term drug release profile was demonstrated. Pharmacological studies in vivo revealed that curcumin nanoparticles significantly improved cognitive function, compared to free curcumin, as evidenced by Morris’s water maze, Y-maze, and novel object recognition tests. Histopathological examination confirmed a significant reduction in amyloid plaque burden and a preserved neuronal architecture in the nanoparticle-treated group. Conclusion: Curcumin administered via nanoparticles would be an effective multi-targeted therapeutic approach against AD.

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Cite this article:
Kanika P, Patel A, Tripathy B. Formulation, characterisation, and evaluation of curcumin nanoparticles in experimental models of alzheimer’s disease. Probecell sci. 2025;2(2):52–61.DOI: https://doi.org/10.65807/prob.sci.2025.2.2.4

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